Cost-utility Analysis of Home Mechanical Ventilation Compared to Hospital Settings in Patients with Amyotrophic Lateral Sclerosis

Abstract Amyotrophic lateral sclerosis is a progressive neuromuscular disease. Mechanical ventilation delays death and use at home can reduce costs increase quality of life. The aim the study comparison mechanical with in healthcare facility for adult patients amyotrophic from societal perspective Czech Republic. Markov model previous was used updated data revelant to perspective, which obtained literature opinions experts companies dealing ventilation. cost-utility analysis carried out over time horizont 10 years results were presented incremental ratio. Accuracy validity verified by probabilistic sensitivity scenario analysis. cumulative are CZK 6,116,394 utilities 8,195,848. 3.55 QALY 3.78 QALY. ratio 9,094,042. Probabilistic do not show significant changes. Home may be considered cost-effective perspective.